Clomicalm® (clomipramine)

Drug description

Tricyclic antidepressant

Formulations available

This medicine is available in tablets and capsules.


Unless otherwise directed by a veterinarian, do not give this medication to animals who are allergic to other antidepressants of the same family or who suffer from problems with digestion, urinary retention, seizures (epilepsy), irregular heartbeat, hyperthyroidism (overproduction of thyroid hormones) or glaucoma (increased pressure in the eye).

It should not be used in pregnant or lactating females and males used for breeding.

Please discuss with a veterinarian or consult the product monograph for more information regarding contraindications.

Side effects

The most common side effects are loss of appetite, vomiting, diarrhea, dry mouth and depression.

The medication can also increase the animal's heart rate.

Please see the product monograph for additional side effects.

Recommended monitoring

The veterinarian in charge of the animal may want to do blood tests to check the condition of the animal's liver before starting treatment and periodically later also.

Drug interactions

Clomicalm® may interfere with the effectiveness of some other drugs if used at the same time. You can ask your veterinarian which ones.

Please also notify the veterinarian if your pet is already taking any drug(s) before starting treatment with Clomicalm®. This will allow him or her to make sure that they are compatible.


Keep at room temperature, away from moisture.


This medication can be administered directly into the mouth of the animal or mixed with food. However, do not hide the tablet in a piece of cheese, as this may cause side effects.

This medication can take between one and three months to take effect.

If accidentally swallowed by a human, contact a poison control center immediately.

Keep out of the reach of children and animals.

If side effects occur and are severe, worsening or continuing, please contact a veterinarian as soon as possible.

Active ingredient



Clomipramine is used in dogs to help treat separation anxiety, obsessive-compulsive disorders and dominance aggression.

In cats, it is used primarily to help treat certain behavioral disorders such as urinary marking.