Tacrolimus is an immunosuppressant used in dogs to treat dry eye syndrome by protecting the lacrimal glands.
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Tacrolimus is an immunosuppressant primarily used in dogs suffering from dry eye syndrome or other autoimmune ocular diseases. It works by inhibiting inflammatory T cells, protecting the lacrimal glands, and stimulating tear production. Administered as ophthalmic drops, it should be stored at room temperature, away from humidity. Side effects may include occasional eyelid hair loss. Regular veterinary monitoring is necessary to assess its effectiveness. This medication is typically prescribed for life to maintain the animal’s eye health.
Tacrolimus
Room temperature
The monitoring of ophthalmic tacrolimus involves regular assessment of treatment effectiveness and potential side effects. It is recommended to measure the animal’s tear production to ensure the medication is working properly. The usual dosage consists of instilling one drop 1 to 2 times a day for several weeks or months, depending on the response to treatment. It is important to wait at least 5 minutes between the application of multiple eye drops to maximize their efficacy. Regular veterinary consultations help adjust the treatment if necessary.
Antibiotics: Macrolides (erythromycin, clarithromycin), rifampicin, aminoglycosides (gentamicin, amikacin) Antifungals: Ketoconazole, itraconazole, fluconazole, voriconazole Antiretrovirals: Ritonavir, lopinavir, atazanavir Antihypertensives: Diltiazem, verapamil, nifedipine Anticonvulsants: Phenobarbital, phenytoin, carbamazepine Antidepressants: Fluoxetine NSAIDs: Ibuprofen, diclofenac
Hypersensitivity to the active substance or any of its excipients Severe liver diseases Immunocompromised patients Severe infections
Headache and dizziness Nausea, vomiting, and diarrhea Tremors and muscle spasms High blood pressure and tachycardia Insomnia and sleep disturbances Increased sensitivity to sunlight Higher risk of infections due to immunosuppression Renal and hepatic toxicity, which can lead to serious complications
Ophthalmic tacrolimus should be used with caution and under veterinary supervision.
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